GISNP9K Forensic Genealogy Inference Kit
In collaboration with the Beijing Forensic Science and Technology Co. Ltd, FGI developed the GISNP9K Forensic Genealogy Inference Kit that detects 9858 SNPs using liquid-phase hybridization capture sequencing technology. It performs genotype and kinship inference testing based on BGI high-throughput sequencing platform. Based on FGI self-developed algorithm and data analysis software, it can accurately infer 1-5 kinship degrees. Moreover, the kit is capable of interpreting the Y-SNP haplotype, mtDNA maternal lineage tracing, blood type, gender determination, eye color, hair color and skin pigmentation.
DNBSEQ-E25 Portable Forensic Sequencer
DNBSEQ-E25 is a portable and easy-to-use forensic sequencer with innovative features of microfluidic based flow cell, self-luminous dye, integrated CMOS detection module and computing module. These new features allow sequencing experiments under more scenarios, making forensic genetic analysis accessible to a wider range of applications.
Product Name | DNBSEQ-E25RS |
Dimensions | 348*312*257mm（L*W*H） |
Net Weight | ＜15kg |
Power Source | Voltage: 100-240V±10% |
Frequency: 50/60Hz | |
Rated Power: 2120VA | |
Computer | Voltage: 24VDC±10% |
Electricity: 5A | |
Screen Type：LCD touch screen | |
Touch Screen | Size: 12.1 inches |
dpi: 1024*800 | |
Max. Sound Pressure | 65dBA |
IP | IPX0 |
Operating Environment | Temperature: 15-30℃ |
Humidity: 20％-80％ RH, non-condensing | |
Max. Altitude: 3000m | |
Storage/Transportation | Temperature: -20℃-50℃ |
Humidity: 15％-85％ RH, non-condensing |
Technical Advantages
1. Innovative Technologies:
l Microfluidic Sequencing Chip: sequencing reagent can directly enter the chip without passing through the instrument.
l Self-luminus Biochemical System: nucleotide signals are generated without external excitation light source.
l Signal Acquisition Module: integrated signal acquisition module directly reads the base signal. No need for traditional optical system.
l Integrated Analysis Module: all-in-one sequencer with built-in analysis module.
2. Enhanced Sequencing Solution:
l Portable: integrated and compact all-in-one sequencer that can perform forensic genetic analysis anytime anywhere.
l Accessible: low-cost plug-and-play sequencer without installation requirements.
l Easy-to-operate: All-in-one cartridge with pre-packaged reagents which does not required reagent preparation.
l Easy-to-maintain: automated sequencing experiments without cleaning requirements.
3. Powerful Kinship Inference Ability:
l Kinship Inference: The kinship inference efficiency within 3rd degree is 100%
The kinship inference efficiency within 4th degree > 99%
The kinship inference efficiency within 5th degree > 98%
The kinship inference efficiency within 6th degree > 90%
l Comprehensive: simultaneous detection of 9858 SNPs in one run, including those from autosomes, Y-chromosome, mitochondria, etc.
l Powerful Practical Functionality: genealogy inference, maternal kinship, paternal lineage, individual identification, phenotype, blood type, etc. Enables multidimensional interpretation of data.
l Cost-effective: small data throughput for each sample, increased number of samples per run.
Technical Principle
Forensic Genealogy Inference Technology is usually defined as the analysis of high density autosomal SNP information obtained from biological samples to infer the degree of kinship between selected individuals. The degree of kinship is a parameter of how related of one individual to another. Higher degrees suggest more distant kinship ties. For immediate family members, degree of kinship equals to the number of meiotic events. For half-siblings, the degree of kinship is the sum of meiotic events of the common ancestor. For full-siblings, the degree of kinship is the sum of meiotic events of the common ancestor subtracted by 1.
FGID Forensic DNA Analysis System
FGID Forensic DNA Analysis System is a massively-parallel sequencing solution developed based on the standard of bioinformatic analysis, which is used in the large-scale analysis of high-frequency single nucleotide polymorphisms (SNPs) and short tandem repeats (STRs). This system is totally compatible with BGI high throughput sequencing platform, providing a one-stop solution starting from the output FASTQ data to the genotyping report or identification report. The system consists of 6 main functional modules: configuration center, sample center, task center, analysis center, report center and identification center. The analysis functions include genotype difference, individual identification, complex kinship, genealogy interpretation, ancestry, etc.
